Endocrine Abstracts

Use of long-term opioid analgesia has increased significantly in the past decade and dependency on prescribed opioids has been described as a ‘public health emergency’ in the United States. Opioid analgesia may be associated with excess mortality when compared to other classes of analgesia used in chronic pain. Opioids exert a range of effects across the hypothalamic-pituitary axes, which are potentially dependent on the chronicity of exposure. The largest body of ev...

Use of long-term opioid analgesia has increased significantly in the past decade and dependency on prescribed opioids has been described as a ‘public health emergency’ in the United States. Opioid analgesia may be associated with excess mortality when compared to other classes of analgesia used in chronic pain. Opioids exert a range of effects across the hypothalamic-pituitary axes, which are potentially dependent on the chronicity of exposure. The largest body of ev...

Introduction: Non-functioning pituitary adenomas (NFPAs) constitute a large proportion of pituitary adenomas and can lead to hypopituitarism and visual field defects. Trans-sphenoidal surgery is the treatment of choice but as a consequence patients may suffer from long-term hormone deficiencies and diabetes insipidus. We sought to examine clinical, pathological, and imaging characteristics of those presenting with NFPAs and subsequent post-surgical outcomes.<p class="abste...

Background: Low glucose is a relatively common primary care referral to specialist endocrine services. However the prevalence of endocrine disease causing endogenous hypoglycaemia is extremely rare.Methods: We obtained all plasma glucose results <4 mM originating from primary care within NHS Lothian, in non-diabetic individuals (20 145 people (77.6% female)) aged 18–40 years, between 2002 and 2017. These data were linked to national admission, m...

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

Introduction: Nephrolithiasis and osteoporosis are more common in people with primary hyperparathyroidism (PHPT), although the clinical factors associated with this risk are not well characterised. Recent evidence has suggested parathyroid hormone concentration, but not calcium, is associated with mortality in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes wi...

Introduction: The performance of biochemical and imaging investigations in contributing towards successful surgical outcomes is not well characterised in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes with PHPT between 2006 and 2014 (n = 611). Parathyroid surgery was performed in 44.8%.Results: PTH was greater than 2x ULN in 34...

Introduction: Radioiodine (RAI) is safe and effective but further information to predict outcomes, specifically treatment failure and residual symptoms following treatment of hypothyroidism, may help improve outcomes.Methods: Retrospective, observational, single-centre study. Electronic medical record review (n= 664) and patient questionnaire (n= 174).Results: Complete cohort: Analysis of outcomes li...

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

Introduction: Nephrolithiasis and osteoporosis are more common in people with primary hyperparathyroidism (PHPT), although the clinical factors associated with this risk are not well characterised. Recent evidence has suggested parathyroid hormone concentration, but not calcium, is associated with mortality in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes wi...